PX Domain
The PX domain of human p40phox bound to PI(3)P (red).
Domain Binding and Function
The Phox homology (PX) domain is the most recently identified member of the family of phospholipid-binding domains. Consisting of ~120 amino acids, the PX domain is found in more than 100 proteins, including the p40phox and p47phox components of the NADPH oxidase complex, sorting nexins, phospholipases D1 and 2 and the kinases PI3K and CISK. Biochemical and cell biology studies have established that PX domains function predominantly as D3-phosphorylated phosphoinositide [PI(3)P] binding modules, targeting the PX domain-containing proteins to the membranes.
Structure Reference
- Bravo, J. et al. (2001), Mol. Cell 8 (4), 829–839.
Examples of Domain Proteins
Binding Examples
| PX Domain Proteins | Binding Partners |
|---|---|
| p40phox | PI(3)P |
| p47phox | PI(3)P |
| Vmp7 | PI(3)P |
