Pro-rich Sequence Binding: WW Domain

Domain Binding and Function

WW domains are small 38 to 40 amino acid residue modules that have been implicated in binding to Pro-rich sequences. WW domains and SH3 domains can potentially bind overlapping sites. In addition, the Pin1 WW domain functions as a phospho-serine or phosphothreonine binding module, suggesting that certain WW domains have evolved an alternate mode of action. WW domains bind peptide ligands with dissociation constants in the µM range.

Structure Reference

1. Ranganathan, R. et al. (1997) Cell 89(6), 875–886.

Examples of Domain Proteins

Binding Examples

WW Domain Proteins	Binding Partners	WW Domain Binding Sites
Yes-Associated Protein (YAP)	Yes, Src-like Tyrosine Kinase	PPPPY
Nedd4 E3 Ubiquitin Ligase	βENaC amiloride-E3 ubiquitin ligase-sensitive epithelial Na+ channel	PPPNY
FBP – 11	Formin	PPLP