Rabbit Monoclonal Antibodies

• New Products

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All Pathways Chromatin Regulation / Acetylation MAP Kinase Signaling Apoptosis and Autophagy Akt Signaling Pathways Translational Control Ca, cAMP & Lipid Signaling Cell Cycle / Checkpoint Control DNA Damage Jak/Stat Pathway NF-κB Signaling TGF-β/Smad Signaling Lymphocyte Signaling Neuroscience Tyrosine Kinases / Adaptors Cytoskeletal Signaling Adhesion Glucose / Energy Metabolism Stem Cell Markers Wnt / Hedgehog / Notch Nuclear Receptor Signaling Protein Folding and Stability Related Products Phosphatases

Rabbit Monoclonal Antibodies for Signal Transduction Research

Akt Signaling PTEN (138G6) Rabbit mAb #9559IHC analysis of paraffin-embedded MDA-MB-468 xenograft (PTEN negative), using Phospho-Akt (Ser473) (736E11) Rabbit mAb (IHC Preferred) #3787 (top) or #9559 (bottom). Note the lack of PTEN staining in the Phospho-Akt positive cells.

Tyrosine Kinase/Docking Proteins Phospho-EGF Receptor (Tyr1173) (53A5) Rabbit mAb #4407IHC analysis of paraffin-embedded human breast carcinoma (top) and human prostate carcinoma (bottom), using #4407.

Neuroscience Phospho-CREB (Ser133) (87G3) Rabbit mAb #9198Confocal microscopic images of SK-N-MC cells showing nuclear staining after 25 minute treatment with Forskolin and IBMX using #9198 (top, red) compared to untreated cells (bottom). Blue pseudocolor = DRAQ5™ (fluorescent DNA dye).

Translational Control Phospho-S6 Ribosomal Protein (Ser235/236) (2F9) Rabbit mAb #4856Flow cytometric analysis of Jurkat cells, untreated (green), or LY294002, Wortmannin and U0126-treated (blue), using #4856 compared to a nonspecific negative control antibody (red).

• Rabbits, often producing better antibodies than mice, allow CST to develop monoclonal antibodies not available to researchers in the past.
• Lot-to-lot consistency expected from a monoclonal antibody.
• All antibodies produced in-house and rigorously tested in applications including IF, IHC and flow cytometry.
• Technical support provided by the scientists who make the antibodies and know them best.

Rabbit Monoclonal Antibodies produced using technology from Epitomics, Inc. (www.epitomics.com) under U.S. Patent No. 5,675,063.

New Rabbit Monoclonal Antibody Products

No.	Name	Released
3430	RhoC (D40E4) Rabbit mAb	12/29/2008
3439	Notch1 (C37C7) Rabbit mAb	12/19/2008
9728	Di-Methyl-Histone H3 (Lys27) (D18C8) Rabbit mAb	12/17/2008
2018	MEP50 (D56B8) Rabbit mAb	12/17/2008
3450	PSD95 (D27E11) Rabbit mAb	12/17/2008
3520	Phospho-NPM (Ser4) (D19C1) Rabbit mAb	12/16/2008
3505	Methyl-PABP1 (Arg455/Arg460) (C60A10) Rabbit mAb	12/15/2008
3443	Phospho-HDAC4 (Ser246)/HDAC5 (Ser259)/HDAC7 (Ser155) (D27B5) Rabbit mAb	12/15/2008
3431	Id2 (D39E8) Rabbit mAb	12/12/2008
4301	p47phox (D21F6) Rabbit mAb	12/12/2008